Type I Interferon Keeps IL-1β in Check
نویسندگان
چکیده
منابع مشابه
Brain type I but not type II IL-1 receptors mediate the effects of IL-1β on behavior in mice.
In the immune system, interleukin (IL)-1β effects are mediated by the type I IL-1 receptors (IL-1RI), whereas the type II IL-1 receptors (IL-1RII) act as inhibitory receptors. IL-1RI and IL-1RII are also present in the brain. To study their functionality in the brain, mice were centrally treated with neutralizing monoclonal antibody (MAb) directed against IL-1RI (35F5, 1 μg) or against IL-1RII ...
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ژورنال
عنوان ژورنال: Cell Host & Microbe
سال: 2016
ISSN: 1931-3128
DOI: 10.1016/j.chom.2016.02.015